Immune System Evasion

Gene Name Onco-Tools Products Description Gene Type NCBI Gene ID Ensembl Gene
B2M beta-2-microglobulin M-B2M-TB1, M-B2M-TB2

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells.

Protein-Coding 567 ENSG00000166710
CD1D CD1d molecule M-CD1D-TB1, M-CD1D-TB2

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers wi

Protein-Coding 912 ENSG00000158473
CD274 CD274 molecule M-CD274-TB1

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells.

Protein-Coding 29126 ENSG00000120217
CSF1 colony stimulating factor 1 M-CSF1-TB1, M-CSF1-TB2

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages.

Protein-Coding 1435 ENSG00000184371
CSF2 colony stimulating factor 2 M-CSF2-TB1

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages.

Protein-Coding 1437 ENSG00000164400
CSF3 colony stimulating factor 3 M-CSF3-TB1

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly.

Protein-Coding 1440 ENSG00000108342
CTLA4 cytotoxic T-lymphocyte associated protein 4 M-CTLA4-TB1, M-CTLA4-TB2

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells.

Protein-Coding 1493 ENSG00000163599
CXCL12 C-X-C motif chemokine ligand 12 M-CXCL12-TB1, M-CXCL12-TB2

This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family.

Protein-Coding 6387 ENSG00000107562
CXCL5 C-X-C motif chemokine ligand 5 M-CXCL5-TB1, M-CXCL5-TB2

This gene encodes a protein that is a member of the CXC subfamily of chemokines.

Protein-Coding 6374 ENSG00000163735
FOXM1 forkhead box M1 M-FOXM1-TB1, M-FOXM1-TB2

The protein encoded by this gene is a transcriptional activator involved in cell proliferation.

Protein-Coding 2305 ENSG00000111206
FOXP3 forkhead box P3 M-FOXP3-TB1, M-FOXP3-TB2

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators.

Protein-Coding 50943 ENSG00000049768
HLA-A major histocompatibility complex, class I, A M-HLA-A-TB1, M-HLA-A-TB2

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin).

Protein-Coding 3105 ENSG00000206503
HLA-B major histocompatibility complex, class I, B M-HLA-B-TB1, M-HLA-B-TB2

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin).

Protein-Coding 3106 ENSG00000234745
HLA-C major histocompatibility complex, class I, C M-HLA-C-TB1, M-HLA-C-TB2

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin).

Protein-Coding 3107 ENSG00000204525
IDO1 indoleamine 2,3-dioxygenase 1 M-IDO1-TB1, M-IDO1-TB2

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine.

Protein-Coding 3620 ENSG00000131203
IDO2 indoleamine 2,3-dioxygenase 2 M-IDO2-TB1, M-IDO2-TB2

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMe

Protein-Coding 169355 ENSG00000188676
KLRB1 killer cell lectin like receptor B1 M-KLRB1-TB1, M-KLRB1-TB2

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation.

Protein-Coding 3820 ENSG00000111796
KLRK1 killer cell lectin like receptor K1 M-KLRK1-TB1, M-KLRK1-TB2

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation.

Protein-Coding 22914 ENSG00000213809
MICA MHC class I polypeptide-related sequence A

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A.

Protein-Coding 100507436 ENSG00000204520
MICB MHC class I polypeptide-related sequence B M-MICB-TB1, M-MICB-TB2, M-MICB-TB3, M-MICB-TB4

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor.

Protein-Coding 4277 ENSG00000204516
MIR150 microRNA 150

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406942 ENSG00000207782
MIR155 microRNA 155

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406947 ENSG00000283904
PDCD1 programmed cell death 1

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation.

Protein-Coding 5133 ENSG00000188389
RAE1 ribonucleic acid export 1

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the enco

Protein-Coding 8480 ENSG00000101146
RAG2 recombination activating 2

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development.

Protein-Coding 5897 ENSG00000175097
TAP1 transporter 1, ATP binding cassette subfamily B member

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.

Protein-Coding 6890 ENSG00000168394
TGFBR2 transforming growth factor beta receptor 2

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily.

Protein-Coding 7048 ENSG00000163513
ULBP1 UL16 binding protein 1

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells.

Protein-Coding 80329 ENSG00000111981