Epigenetic Regulation

Gene Name Onco-Tools Products Description Gene Type NCBI Gene ID Ensembl Gene
BMI1 BMI1 proto-oncogene, polycomb ring finger

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1).

Protein-Coding 648 ENSG00000168283
CDKN2B-AS1 CDKN2B antisense RNA 1

This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21.

Protein-Coding 100048912 ENSG00000240498
CREBBP CREB binding protein

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors.

Protein-Coding 1387 ENSG00000005339
DNMT1 DNA methyltransferase 1

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA.

Protein-Coding 1786 ENSG00000130816
DNMT3A DNA methyltransferase 3 alpha

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation.

Protein-Coding 1788 ENSG00000119772
DNMT3B DNA methyltransferase 3 beta

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation.

Protein-Coding 1789 ENSG00000088305
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit

This gene encodes a member of the Polycomb-group (PcG) family.

Protein-Coding 2146 ENSG00000106462
HAT1 histone acetyltransferase 1

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the

Protein-Coding 8520 ENSG00000128708
HDAC1 histone deacetylase 1

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression.

Protein-Coding 3065 ENSG00000116478
HDAC11 histone deacetylase 11

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10.

Protein-Coding 79885 ENSG00000163517
HDAC2 histone deacetylase 2

This gene product belongs to the histone deacetylase family.

Protein-Coding 3066 ENSG00000196591
HDAC3 histone deacetylase 3

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Protein-Coding 8841 ENSG00000171720
HDAC4 histone deacetylase 4

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Protein-Coding 9759 ENSG00000068024
HDAC5 histone deacetylase 5

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Protein-Coding 10014 ENSG00000108840
HDAC6 histone deacetylase 6

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Protein-Coding 10013 ENSG00000094631
HDAC7 histone deacetylase 7

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Protein-Coding 51564 ENSG00000061273
HDAC8 histone deacetylase 8

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Protein-Coding 55869 ENSG00000147099
HDAC9 histone deacetylase 9

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.

Protein-Coding 9734 ENSG00000048052
HOTAIR HOX transcript antisense RNA

This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes.

Non-Coding 100124700 ENSG00000228630
HOTTIP HOXA distal transcript antisense RNA Non-Coding 100316868
JAK2 Janus kinase 2

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways.

Protein-Coding 3717 ENSG00000096968
KAT2A lysine acetyltransferase 2A

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator.

Protein-Coding 2648 ENSG00000108773
KAT2B lysine acetyltransferase 2B

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A.

Protein-Coding 8850 ENSG00000114166
KAT5 lysine acetyltransferase 5

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein.

Protein-Coding 10524 ENSG00000172977
KAT6A lysine acetyltransferase 6A

This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases.

Protein-Coding 7994 ENSG00000083168
KAT6B lysine acetyltransferase 6B

The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex.

Protein-Coding 23522 ENSG00000156650
KDM1A lysine demethylase 1A

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain.

Protein-Coding 23028 ENSG00000004487
KDM1B lysine demethylase 1B

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 1

Protein-Coding 221656 ENSG00000165097
KDM2A lysine demethylase 2A

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

Protein-Coding 22992 ENSG00000173120
KDM2B lysine demethylase 2B

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

Protein-Coding 84678 ENSG00000089094
KDM4A lysine demethylase 4A

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers.

Protein-Coding 9682 ENSG00000066135
KDM4B lysine demethylase 4B Protein-Coding 23030 ENSG00000127663
KDM6A lysine demethylase 6A

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein.

Protein-Coding 7403 ENSG00000147050
KDM6B lysine demethylase 6B

The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3).

Protein-Coding 23135 ENSG00000132510
MDC1 mediator of DNA damage checkpoint 1

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence.

Protein-Coding 9656 ENSG00000137337
MIR101-1 microRNA 101-1

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406893 ENSG00000199135
MIR140 microRNA 140

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406932 ENSG00000208017
MIR143 microRNA 143

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406935 ENSG00000284182
MIR152 microRNA 152

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406943 ENSG00000207947
MIR185 microRNA 185

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406961 ENSG00000208023
MIR449A microRNA 449a

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 554213 ENSG00000198983
PCAT1 prostate cancer associated transcript 1 Non-Coding 100750225 ENSG00000253438
PKN1 protein kinase N1

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway.

Protein-Coding 5585 ENSG00000123143
PRMT1 protein arginine methyltransferase 1

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family.

Protein-Coding 3276 ENSG00000126457
PRMT3 protein arginine methyltransferase 3

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins.

Protein-Coding 10196 ENSG00000185238
PRMT5 protein arginine methyltransferase 5

This gene encodes an enzyme that belongs to the methyltransferase family.

Protein-Coding 10419 ENSG00000100462
PRMT6 protein arginine methyltransferase 6

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens

Protein-Coding 55170 ENSG00000198890
PRMT7 protein arginine methyltransferase 7

Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor.

Protein-Coding 54496 ENSG00000132600
RCC1 regulator of chromosome condensation 1 Protein-Coding 1104 ENSG00000180198
RPS6KA3 ribosomal protein S6 kinase A3

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases.

Protein-Coding 6197 ENSG00000177189
RPS6KA4 ribosomal protein S6 kinase A4

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases.

Protein-Coding 8986 ENSG00000162302
RPS6KA5 ribosomal protein S6 kinase A5

This gene encodes for a Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1

Protein-Coding 9252 ENSG00000100784
SMYD3 SET and MYND domain containing 3

This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase.

Protein-Coding 64754 ENSG00000185420
SUV39H1 suppressor of variegation 3-9 homolog 1

This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain.

Protein-Coding 6839 ENSG00000101945
SUV39H2 suppressor of variegation 3-9 homolog 2 Protein-Coding 79723 ENSG00000152455
SUZ12 SUZ12 polycomb repressive complex 2 subunit

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma.

Protein-Coding 23512 ENSG00000178691
XIST X inactive specific transcript

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females.

Non-Coding 7503 ENSG00000229807