Cell Signaling

Gene Name Onco-Tools Products Description Gene Type NCBI Gene ID Ensembl Gene
AKT1 AKT serine/threonine kinase 1 M-AKT1-TB1, M-AKT1-TB2

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts.

Protein-Coding 207 ENSG00000142208
AKT2 AKT serine/threonine kinase 2

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains.

Protein-Coding 208 ENSG00000105221
APC APC, WNT signaling pathway regulator

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway.

Protein-Coding 324 ENSG00000134982
AR androgen receptor M-AR-TB1, M-AR-TB2

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.

Protein-Coding 367 ENSG00000169083
AXIN1 axin 1 M-AXIN1-TB1, M-AXIN1-TB2

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain.

Protein-Coding 8312 ENSG00000103126
BRAF B-Raf proto-oncogene, serine/threonine kinase M-BRAF-TB1

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases.

Protein-Coding 673 ENSG00000157764
CDH1 cadherin 1 M-CDH1-TB1, M-CDH1-TB2

This gene encodes a classical cadherin of the cadherin superfamily.

Protein-Coding 999 ENSG00000039068
CTNNA1 catenin alpha 1

This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments insid

Protein-Coding 1495 ENSG00000044115
CTNNB1 catenin beta 1 M-CTNNB1-TB1, M-CTNNB1-TB2

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs).

Protein-Coding 1499 ENSG00000168036
EGFR epidermal growth factor receptor

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family.

Protein-Coding 1956 ENSG00000146648
ERBB2 erb-b2 receptor tyrosine kinase 2

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.

Protein-Coding 2064 ENSG00000141736
ESR1 estrogen receptor 1

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.

Protein-Coding 2099 ENSG00000091831
ESR2 estrogen receptor 2

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors.

Protein-Coding 2100 ENSG00000140009
FGFR2 fibroblast growth factor receptor 2

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution.

Protein-Coding 2263 ENSG00000066468
FOS Fos proto-oncogene, AP-1 transcription factor subunit M-FOS-TB1, M-FOS-TB2

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2.

Protein-Coding 2353 ENSG00000170345
FOXO1 forkhead box O1 M-FOXO1-TB1, M-FOXO1-TB2

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain.

Protein-Coding 2308 ENSG00000150907
GLI1 GLI family zinc finger 1

This gene encodes a member of the Kruppel family of zinc finger proteins.

Protein-Coding 2735 ENSG00000111087
GPC3 glypican 3 M-GPC3-TB1, M-GPC3-TB2

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains.

Protein-Coding 2719 ENSG00000147257
HRAS HRas proto-oncogene, GTPase M-HRAS-TB1, M-HRAS-TB2

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses.

Protein-Coding 3265 ENSG00000174775,ENSG00000276536
IGF1 insulin like growth factor 1

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development.

Protein-Coding 3479 ENSG00000017427
IGF1R insulin like growth factor 1 receptor M-IGF1R-TB1, M-IGF1R-TB2

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events.

Protein-Coding 3480 ENSG00000140443
IGF2 insulin like growth factor 2

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth.

Protein-Coding 3481 ENSG00000167244
IGF2R insulin like growth factor 2 receptor M-IGF2R-TB1, M-IGF2R-TB2

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein.

Protein-Coding 3482 ENSG00000197081
INPP4B inositol polyphosphate-4-phosphatase type II B

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways.

Protein-Coding 8821 ENSG00000109452
INSR insulin receptor M-INSR-TB1, M-INSR-TB2

This gene encodes a member of the receptor tyrosine kinase family of proteins.

Protein-Coding 3643 ENSG00000171105
JUN Jun proto-oncogene, AP-1 transcription factor subunit M-JUN-TB1, M-JUN-TB2

This gene is the putative transforming gene of avian sarcoma virus 17.

Protein-Coding 3725 ENSG00000177606
KIT KIT proto-oncogene receptor tyrosine kinase M-KIT-TB1, M-KIT-TB2

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.

Protein-Coding 3815 ENSG00000157404
KRAS KRAS proto-oncogene, GTPase M-KRAS-TB1, M-KRAS-TB2

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily.

Protein-Coding 3845 ENSG00000133703
MAP2K1 mitogen-activated protein kinase kinase 1 M-MAP2K1-TB1, M-MAP2K1-TB2

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase.

Protein-Coding 5604 ENSG00000169032
MAP2K2 mitogen-activated protein kinase kinase 2 M-MAP2K2-TB1

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.

Protein-Coding 5605 ENSG00000126934
MAP2K3 mitogen-activated protein kinase kinase 3

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.

Protein-Coding 5606 ENSG00000034152
MAP2K4 mitogen-activated protein kinase kinase 4 M-MAP2K4-TB1, M-MAP2K4-TB2

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family.

Protein-Coding 6416 ENSG00000065559
MAP2K5 mitogen-activated protein kinase kinase 5 M-MAP2K5-TB1, M-MAP2K5-TB2

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5.

Protein-Coding 5607 ENSG00000137764
MAP2K6 mitogen-activated protein kinase kinase 6

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase.

Protein-Coding 5608 ENSG00000108984
MAP2K7 mitogen-activated protein kinase kinase 7 M-MAP2K7-TB1, M-MAP2K7-TB2

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.

Protein-Coding 5609 ENSG00000076984
MAP3K2 mitogen-activated protein kinase kinase kinase 2 M-MAP3K2-TB1, M-MAP3K2-TB2

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway.

Protein-Coding 10746 ENSG00000169967
MAP3K3 mitogen-activated protein kinase kinase kinase 3 M-MAP3K3-TB1, M-MAP3K3-TB2

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3.

Protein-Coding 4215 ENSG00000198909
MAP3K4 mitogen-activated protein kinase kinase kinase 4 M-MAP3K4-TB1, M-MAP3K4-TB2

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specifi

Protein-Coding 4216 ENSG00000085511
MAPK1 mitogen-activated protein kinase 1 M-MAPK1-TB1, M-MAPK1-TB2

This gene encodes a member of the MAP kinase family.

Protein-Coding 5594 ENSG00000100030
MAPK10 mitogen-activated protein kinase 10

The protein encoded by this gene is a member of the MAP kinase family.

Protein-Coding 5602 ENSG00000109339
MAPK14 mitogen-activated protein kinase 14 M-MAPK14-TB1, M-MAPK14-TB2

The protein encoded by this gene is a member of the MAP kinase family.

Protein-Coding 1432 ENSG00000112062
MAPK3 mitogen-activated protein kinase 3 M-MAPK3-TB1, M-MAPK3-TB2

The protein encoded by this gene is a member of the MAP kinase family.

Protein-Coding 5595 ENSG00000102882
MAPK7 mitogen-activated protein kinase 7

The protein encoded by this gene is a member of the MAP kinase family.

Protein-Coding 5598 ENSG00000166484
MAPK8 mitogen-activated protein kinase 8

The protein encoded by this gene is a member of the MAP kinase family.

Protein-Coding 5599 ENSG00000107643
MAPK9 mitogen-activated protein kinase 9 M-MAPK9-TB1, M-MAPK9-TB2

The protein encoded by this gene is a member of the MAP kinase family.

Protein-Coding 5601 ENSG00000050748
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 M-MAPKAPK2-TB1, M-MAPKAPK2-TB2

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase.

Protein-Coding 9261 ENSG00000162889
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 M-MAPKAPK3-TB1, M-MAPKAPK3-TB2

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase.

Protein-Coding 7867 ENSG00000114738
MEN1 menin 1

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1.

Protein-Coding 4221 ENSG00000133895
MKNK1 MAP kinase interacting serine/threonine kinase 1 M-MKNK1-TB1, M-MKNK1-TB2

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress

Protein-Coding 8569 ENSG00000079277
MKNK2 MAP kinase interacting serine/threonine kinase 2 M-MKNK2-TB1

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily.

Protein-Coding 2872 ENSG00000099875
MYC v-myc avian myelocytomatosis viral oncogene homolog M-MYC-TB1, M-MYC-TB2

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.

Protein-Coding 4609 ENSG00000136997
NF1 neurofibromin 1 M-NF1-TB1, M-NF1-TB2

This gene product appears to function as a negative regulator of the ras signal transduction pathway.

Protein-Coding 4763 ENSG00000196712
NF2 neurofibromin 2 M-NF2-TB1

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membran

Protein-Coding 4771 ENSG00000186575
NOTCH1 notch 1

This gene encodes a member of the NOTCH family of proteins.

Protein-Coding 4851 ENSG00000148400
NRAS neuroblastoma RAS viral oncogene homolog M-NRAS-TB1, M-NRAS-TB2

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane.

Protein-Coding 4893 ENSG00000213281
PGR progesterone receptor

This gene encodes a member of the steroid receptor superfamily.

Protein-Coding 5241 ENSG00000082175
PTCH1 patched 1

This gene encodes a member of the patched gene family.

Protein-Coding 5727 ENSG00000185920
PTEN phosphatase and tensin homolog M-PTEN-TB1, M-PTEN-TB2

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.

Protein-Coding 5728 ENSG00000171862
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) M-RAC1-TB1, M-RAC1-TB2

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins.

Protein-Coding 5879 ENSG00000136238
RARA retinoic acid receptor alpha M-RARA-TB1, M-RARA-TB2

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner.

Protein-Coding 5914 ENSG00000131759
RARB retinoic acid receptor beta

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators.

Protein-Coding 5915 ENSG00000077092
RPS6KA4 ribosomal protein S6 kinase A4

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases.

Protein-Coding 8986 ENSG00000162302
RPS6KA5 ribosomal protein S6 kinase A5

This gene encodes for a Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1

Protein-Coding 9252 ENSG00000100784
SHH sonic hedgehog

This gene encodes a protein that is instrumental in patterning the early embryo.

Protein-Coding 6469 ENSG00000164690
SMAD2 SMAD family member 2

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C.

Protein-Coding 4087 ENSG00000175387
SMAD3 SMAD family member 3

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C.

Protein-Coding 4088 ENSG00000166949
SMAD4 SMAD family member 4

This gene encodes a member of the Smad family of signal transduction proteins.

Protein-Coding 4089 ENSG00000141646
SMO smoothened, frizzled class receptor

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins.

Protein-Coding 6608 ENSG00000128602
STK11 serine/threonine kinase 11 M-STK11-TB1, M-STK11-TB2

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor.

Protein-Coding 6794 ENSG00000118046
STK36 serine/threonine kinase 36

This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway.

Protein-Coding 27148 ENSG00000163482
TGFB1 transforming growth factor beta 1

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins.

Protein-Coding 7040 ENSG00000105329
TSC1 tuberous sclerosis 1

This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis.

Protein-Coding 7248 ENSG00000165699
TSC2 tuberous sclerosis 2

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases.

Protein-Coding 7249 ENSG00000103197
VHL von Hippel-Lindau tumor suppressor

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors.

Protein-Coding 7428 ENSG00000134086
WNT1 Wnt family member 1

The WNT gene family consists of structurally related genes which encode secreted signaling proteins.

Protein-Coding 7471 ENSG00000125084
WNT5A Wnt family member 5A

The WNT gene family consists of structurally related genes which encode secreted signaling proteins.

Protein-Coding 7474 ENSG00000114251