Cell Signaling
Gene | Name | Onco-Tools Products | Description | Gene Type | NCBI Gene ID | Ensembl Gene |
---|---|---|---|---|---|---|
AKT1 | AKT serine/threonine kinase 1 | M-AKT1-TB1, M-AKT1-TB2 |
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. |
Protein-Coding | 207 | ENSG00000142208 |
AKT2 | AKT serine/threonine kinase 2 |
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. |
Protein-Coding | 208 | ENSG00000105221 | |
APC | APC, WNT signaling pathway regulator |
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. |
Protein-Coding | 324 | ENSG00000134982 | |
AR | androgen receptor | M-AR-TB1, M-AR-TB2 |
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. |
Protein-Coding | 367 | ENSG00000169083 |
AXIN1 | axin 1 | M-AXIN1-TB1, M-AXIN1-TB2 |
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. |
Protein-Coding | 8312 | ENSG00000103126 |
BRAF | B-Raf proto-oncogene, serine/threonine kinase | M-BRAF-TB1 |
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. |
Protein-Coding | 673 | ENSG00000157764 |
CDH1 | cadherin 1 | M-CDH1-TB1, M-CDH1-TB2 |
This gene encodes a classical cadherin of the cadherin superfamily. |
Protein-Coding | 999 | ENSG00000039068 |
CTNNA1 | catenin alpha 1 |
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments insid |
Protein-Coding | 1495 | ENSG00000044115 | |
CTNNB1 | catenin beta 1 | M-CTNNB1-TB1, M-CTNNB1-TB2 |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). |
Protein-Coding | 1499 | ENSG00000168036 |
EGFR | epidermal growth factor receptor |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. |
Protein-Coding | 1956 | ENSG00000146648 | |
ERBB2 | erb-b2 receptor tyrosine kinase 2 |
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. |
Protein-Coding | 2064 | ENSG00000141736 | |
ESR1 | estrogen receptor 1 |
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. |
Protein-Coding | 2099 | ENSG00000091831 | |
ESR2 | estrogen receptor 2 |
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. |
Protein-Coding | 2100 | ENSG00000140009 | |
FGFR2 | fibroblast growth factor receptor 2 |
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. |
Protein-Coding | 2263 | ENSG00000066468 | |
FOS | Fos proto-oncogene, AP-1 transcription factor subunit | M-FOS-TB1, M-FOS-TB2 |
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. |
Protein-Coding | 2353 | ENSG00000170345 |
FOXO1 | forkhead box O1 | M-FOXO1-TB1, M-FOXO1-TB2 |
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. |
Protein-Coding | 2308 | ENSG00000150907 |
GLI1 | GLI family zinc finger 1 |
This gene encodes a member of the Kruppel family of zinc finger proteins. |
Protein-Coding | 2735 | ENSG00000111087 | |
GPC3 | glypican 3 | M-GPC3-TB1, M-GPC3-TB2 |
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. |
Protein-Coding | 2719 | ENSG00000147257 |
HRAS | HRas proto-oncogene, GTPase | M-HRAS-TB1, M-HRAS-TB2 |
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. |
Protein-Coding | 3265 | ENSG00000174775,ENSG00000276536 |
IGF1 | insulin like growth factor 1 |
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. |
Protein-Coding | 3479 | ENSG00000017427 | |
IGF1R | insulin like growth factor 1 receptor | M-IGF1R-TB1, M-IGF1R-TB2 |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. |
Protein-Coding | 3480 | ENSG00000140443 |
IGF2 | insulin like growth factor 2 |
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. |
Protein-Coding | 3481 | ENSG00000167244 | |
IGF2R | insulin like growth factor 2 receptor | M-IGF2R-TB1, M-IGF2R-TB2 |
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. |
Protein-Coding | 3482 | ENSG00000197081 |
INPP4B | inositol polyphosphate-4-phosphatase type II B |
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. |
Protein-Coding | 8821 | ENSG00000109452 | |
INSR | insulin receptor | M-INSR-TB1, M-INSR-TB2 |
This gene encodes a member of the receptor tyrosine kinase family of proteins. |
Protein-Coding | 3643 | ENSG00000171105 |
JUN | Jun proto-oncogene, AP-1 transcription factor subunit | M-JUN-TB1, M-JUN-TB2 |
This gene is the putative transforming gene of avian sarcoma virus 17. |
Protein-Coding | 3725 | ENSG00000177606 |
KIT | KIT proto-oncogene receptor tyrosine kinase | M-KIT-TB1, M-KIT-TB2 |
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. |
Protein-Coding | 3815 | ENSG00000157404 |
KRAS | KRAS proto-oncogene, GTPase | M-KRAS-TB1, M-KRAS-TB2 |
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. |
Protein-Coding | 3845 | ENSG00000133703 |
MAP2K1 | mitogen-activated protein kinase kinase 1 | M-MAP2K1-TB1, M-MAP2K1-TB2 |
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. |
Protein-Coding | 5604 | ENSG00000169032 |
MAP2K2 | mitogen-activated protein kinase kinase 2 | M-MAP2K2-TB1 |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. |
Protein-Coding | 5605 | ENSG00000126934 |
MAP2K3 | mitogen-activated protein kinase kinase 3 |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. |
Protein-Coding | 5606 | ENSG00000034152 | |
MAP2K4 | mitogen-activated protein kinase kinase 4 | M-MAP2K4-TB1, M-MAP2K4-TB2 |
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. |
Protein-Coding | 6416 | ENSG00000065559 |
MAP2K5 | mitogen-activated protein kinase kinase 5 | M-MAP2K5-TB1, M-MAP2K5-TB2 |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. |
Protein-Coding | 5607 | ENSG00000137764 |
MAP2K6 | mitogen-activated protein kinase kinase 6 |
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. |
Protein-Coding | 5608 | ENSG00000108984 | |
MAP2K7 | mitogen-activated protein kinase kinase 7 | M-MAP2K7-TB1, M-MAP2K7-TB2 |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. |
Protein-Coding | 5609 | ENSG00000076984 |
MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | M-MAP3K2-TB1, M-MAP3K2-TB2 |
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. |
Protein-Coding | 10746 | ENSG00000169967 |
MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | M-MAP3K3-TB1, M-MAP3K3-TB2 |
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. |
Protein-Coding | 4215 | ENSG00000198909 |
MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | M-MAP3K4-TB1, M-MAP3K4-TB2 |
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specifi |
Protein-Coding | 4216 | ENSG00000085511 |
MAPK1 | mitogen-activated protein kinase 1 | M-MAPK1-TB1, M-MAPK1-TB2 |
This gene encodes a member of the MAP kinase family. |
Protein-Coding | 5594 | ENSG00000100030 |
MAPK10 | mitogen-activated protein kinase 10 |
The protein encoded by this gene is a member of the MAP kinase family. |
Protein-Coding | 5602 | ENSG00000109339 | |
MAPK14 | mitogen-activated protein kinase 14 | M-MAPK14-TB1, M-MAPK14-TB2 |
The protein encoded by this gene is a member of the MAP kinase family. |
Protein-Coding | 1432 | ENSG00000112062 |
MAPK3 | mitogen-activated protein kinase 3 | M-MAPK3-TB1, M-MAPK3-TB2 |
The protein encoded by this gene is a member of the MAP kinase family. |
Protein-Coding | 5595 | ENSG00000102882 |
MAPK7 | mitogen-activated protein kinase 7 |
The protein encoded by this gene is a member of the MAP kinase family. |
Protein-Coding | 5598 | ENSG00000166484 | |
MAPK8 | mitogen-activated protein kinase 8 |
The protein encoded by this gene is a member of the MAP kinase family. |
Protein-Coding | 5599 | ENSG00000107643 | |
MAPK9 | mitogen-activated protein kinase 9 | M-MAPK9-TB1, M-MAPK9-TB2 |
The protein encoded by this gene is a member of the MAP kinase family. |
Protein-Coding | 5601 | ENSG00000050748 |
MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | M-MAPKAPK2-TB1, M-MAPKAPK2-TB2 |
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. |
Protein-Coding | 9261 | ENSG00000162889 |
MAPKAPK3 | mitogen-activated protein kinase-activated protein kinase 3 | M-MAPKAPK3-TB1, M-MAPKAPK3-TB2 |
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. |
Protein-Coding | 7867 | ENSG00000114738 |
MEN1 | menin 1 |
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. |
Protein-Coding | 4221 | ENSG00000133895 | |
MKNK1 | MAP kinase interacting serine/threonine kinase 1 | M-MKNK1-TB1, M-MKNK1-TB2 |
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress |
Protein-Coding | 8569 | ENSG00000079277 |
MKNK2 | MAP kinase interacting serine/threonine kinase 2 | M-MKNK2-TB1 |
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. |
Protein-Coding | 2872 | ENSG00000099875 |
MYC | v-myc avian myelocytomatosis viral oncogene homolog | M-MYC-TB1, M-MYC-TB2 |
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. |
Protein-Coding | 4609 | ENSG00000136997 |
NF1 | neurofibromin 1 | M-NF1-TB1, M-NF1-TB2 |
This gene product appears to function as a negative regulator of the ras signal transduction pathway. |
Protein-Coding | 4763 | ENSG00000196712 |
NF2 | neurofibromin 2 | M-NF2-TB1 |
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membran |
Protein-Coding | 4771 | ENSG00000186575 |
NOTCH1 | notch 1 |
This gene encodes a member of the NOTCH family of proteins. |
Protein-Coding | 4851 | ENSG00000148400 | |
NRAS | neuroblastoma RAS viral oncogene homolog | M-NRAS-TB1, M-NRAS-TB2 |
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. |
Protein-Coding | 4893 | ENSG00000213281 |
PGR | progesterone receptor |
This gene encodes a member of the steroid receptor superfamily. |
Protein-Coding | 5241 | ENSG00000082175 | |
PTCH1 | patched 1 |
This gene encodes a member of the patched gene family. |
Protein-Coding | 5727 | ENSG00000185920 | |
PTEN | phosphatase and tensin homolog | M-PTEN-TB1, M-PTEN-TB2 |
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. |
Protein-Coding | 5728 | ENSG00000171862 |
RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | M-RAC1-TB1, M-RAC1-TB2 |
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. |
Protein-Coding | 5879 | ENSG00000136238 |
RARA | retinoic acid receptor alpha | M-RARA-TB1, M-RARA-TB2 |
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. |
Protein-Coding | 5914 | ENSG00000131759 |
RARB | retinoic acid receptor beta |
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. |
Protein-Coding | 5915 | ENSG00000077092 | |
RPS6KA4 | ribosomal protein S6 kinase A4 |
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. |
Protein-Coding | 8986 | ENSG00000162302 | |
RPS6KA5 | ribosomal protein S6 kinase A5 |
This gene encodes for a Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 |
Protein-Coding | 9252 | ENSG00000100784 | |
SHH | sonic hedgehog |
This gene encodes a protein that is instrumental in patterning the early embryo. |
Protein-Coding | 6469 | ENSG00000164690 | |
SMAD2 | SMAD family member 2 |
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. |
Protein-Coding | 4087 | ENSG00000175387 | |
SMAD3 | SMAD family member 3 |
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. |
Protein-Coding | 4088 | ENSG00000166949 | |
SMAD4 | SMAD family member 4 |
This gene encodes a member of the Smad family of signal transduction proteins. |
Protein-Coding | 4089 | ENSG00000141646 | |
SMO | smoothened, frizzled class receptor |
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. |
Protein-Coding | 6608 | ENSG00000128602 | |
STK11 | serine/threonine kinase 11 | M-STK11-TB1, M-STK11-TB2 |
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. |
Protein-Coding | 6794 | ENSG00000118046 |
STK36 | serine/threonine kinase 36 |
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. |
Protein-Coding | 27148 | ENSG00000163482 | |
TGFB1 | transforming growth factor beta 1 |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. |
Protein-Coding | 7040 | ENSG00000105329 | |
TSC1 | tuberous sclerosis 1 |
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. |
Protein-Coding | 7248 | ENSG00000165699 | |
TSC2 | tuberous sclerosis 2 |
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. |
Protein-Coding | 7249 | ENSG00000103197 | |
VHL | von Hippel-Lindau tumor suppressor |
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. |
Protein-Coding | 7428 | ENSG00000134086 | |
WNT1 | Wnt family member 1 |
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. |
Protein-Coding | 7471 | ENSG00000125084 | |
WNT5A | Wnt family member 5A |
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. |
Protein-Coding | 7474 | ENSG00000114251 |