Cell Cycle & DNA Repair

Gene Name Onco-Tools Products Description Gene Type NCBI Gene ID Ensembl Gene
ATM ATM serine/threonine kinase M-ATM-TB1

The protein encoded by this gene belongs to the PI3/PI4-kinase family.

Protein-Coding 472 ENSG00000149311
ATR ATR serine/threonine kinase M-ATR-TB1, M-ATR-TB2

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia.

Protein-Coding 545 ENSG00000175054
AURKA aurora kinase A

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation.

Protein-Coding 6790 ENSG00000087586
BRCA1 BRCA1, DNA repair associated M-BRCA1-TB1

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor.

Protein-Coding 672 ENSG00000012048
BRCA2 BRCA2, DNA repair associated M-BRCA2-TB1, M-BRCA2-TB2

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer.

Protein-Coding 675 ENSG00000139618
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B M-BUB1B-TB1, M-BUB1B-TB2

This gene encodes a kinase involved in spindle checkpoint function.

Protein-Coding 701 ENSG00000156970
CCNA2 cyclin A2 M-CCNA2-TB1, M-CCNA2-TB2

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle.

Protein-Coding 890 ENSG00000145386
CCNB1 cyclin B1 M-CCNB1-TB1, M-CCNB1-TB2

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF).

Protein-Coding 891 ENSG00000134057
CCNC cyclin C M-CCNC-TB1, M-CCNC-TB2, M-CCNC-TB3, M-CCNC-TB4

The protein encoded by this gene is a member of the cyclin family of proteins.

Protein-Coding 892 ENSG00000112237
CCND1 cyclin D1 M-CCND1-TB1, M-CCND1-TB2, M-CCND1-TB3, M-CCND1-TB4

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle.

Protein-Coding 595 ENSG00000110092
CCND2 cyclin D2 M-CCND2-TB1, M-CCND2-TB2

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.

Protein-Coding 894 ENSG00000118971
CCND3 cyclin D3

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.

Protein-Coding 896 ENSG00000112576
CCNE1 cyclin E1 M-CCNE1-TB1, M-CCNE1-TB2, M-CCNE1-TB3, M-CCNE1-TB4

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.

Protein-Coding 898 ENSG00000105173
CCNF cyclin F M-CCNF-TB1, M-CCNF-TB2, M-CCNF-TB3, M-CCNF-TB4

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases.

Protein-Coding 899 ENSG00000162063
CCNG1 cyclin G1 M-CCNG1-TB1, M-CCNG1-TB2

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors.

Protein-Coding 900 ENSG00000113328
CCNG2 cyclin G2 M-CCNG2-TB1, M-CCNG2-TB2

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors.

Protein-Coding 901 ENSG00000138764
CCNH cyclin H M-CCNH-TB1, M-CCNH-TB2, M-CCNH-TB3, M-CCNH-TB4

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.

Protein-Coding 902 ENSG00000134480
CCNT1 cyclin T1 M-CCNT1-TB1, M-CCNT1-TB2

This gene encodes a member of the highly conserved cyclin C subfamily.

Protein-Coding 904 ENSG00000129315
CCNT2 cyclin T2 M-CCNT2-TB1, M-CCNT2-TB2

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.

Protein-Coding 905 ENSG00000082258
CDC20 cell division cycle 20 M-CDC20-TB1, M-CDC20-TB2

CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle.

Protein-Coding 991 ENSG00000117399
CDC25A cell division cycle 25A M-CDC25A-TB1, M-CDC25A-TB2

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle.

Protein-Coding 993 ENSG00000164045
CDC25B cell division cycle 25B

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis.

Protein-Coding 994 ENSG00000101224
CDC25C cell division cycle 25C M-CDC25C-TB1, M-CDC25C-TB2, M-CDC25C-TB3, M-CDC25C-TB4

This gene encodes a conserved protein that plays a key role in the regulation of cell division.

Protein-Coding 995 ENSG00000158402
CDC27 cell division cycle 27 M-CDC27-TB1, M-CDC27-TB2

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2.

Protein-Coding 996 ENSG00000004897
CDK1 cyclin dependent kinase 1 M-CDK1-TB1, M-CDK1-TB2

The protein encoded by this gene is a member of the Ser/Thr protein kinase family.

Protein-Coding 983 ENSG00000170312
CDK2 cyclin dependent kinase 2 M-CDK2-TB1, M-CDK2-TB2

This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation.

Protein-Coding 1017 ENSG00000123374
CDK3 cyclin dependent kinase 3 M-CDK3-TB1, M-CDK3-TB2

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors.

Protein-Coding 1018 ENSG00000250506
CDK4 cyclin dependent kinase 4 M-CDK4-TB1, M-CDK4-TB2

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2.

Protein-Coding 1019 ENSG00000135446
CDK5 cyclin dependent kinase 5 M-CDK5-TB1, M-CDK5-TB2

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins.

Protein-Coding 1020 ENSG00000164885
CDK6 cyclin dependent kinase 6 M-CDK6-TB1, M-CDK6-TB2

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family.

Protein-Coding 1021 ENSG00000105810
CDK7 cyclin dependent kinase 7 M-CDK7-TB1, M-CDK7-TB2, M-CDK7-TB3, M-CDK7-TB4

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family.

Protein-Coding 1022 ENSG00000277273,ENSG00000134058
CDK8 cyclin dependent kinase 8 M-CDK8-TB1, M-CDK8-TB2

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression.

Protein-Coding 1024 ENSG00000132964
CDK9 cyclin dependent kinase 9 M-CDK9-TB1, M-CDK9-TB2

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S.

Protein-Coding 1025 ENSG00000136807
CDKN1A cyclin dependent kinase inhibitor 1A M-CDKN1A-TB1, M-CDKN1A-TB2

This gene encodes a potent cyclin-dependent kinase inhibitor.

Protein-Coding 1026 ENSG00000124762
CDKN1B cyclin dependent kinase inhibitor 1B M-CDKN1B-TB1, M-CDKN1B-TB2

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21.

Protein-Coding 1027 ENSG00000111276
CDKN1C cyclin dependent kinase inhibitor 1C M-CDKN1C-TB1, M-CDKN1C-TB2, M-CDKN1C-TB3, M-CDKN1C-TB4

This gene is imprinted, with preferential expression of the maternal allele.

Protein-Coding 1028 ENSG00000273707,ENSG00000129757
CDKN2A cyclin dependent kinase inhibitor 2A M-CDKN2A-TB1, M-CDKN2A-TB2, M-CDKN2A-TB3, M-CDKN2A-TB4

This gene generates several transcript variants which differ in their first exons.

Protein-Coding 1029 ENSG00000147889
CDKN2B cyclin dependent kinase inhibitor 2B M-CDKN2B-TB1, M-CDKN2B-TB2

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors.

Protein-Coding 1030 ENSG00000147883
CDKN2C cyclin dependent kinase inhibitor 2C M-CDKN2C-TB1

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors.

Protein-Coding 1031 ENSG00000123080
CDKN2D cyclin dependent kinase inhibitor 2D M-CDKN2D-TB1

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors.

Protein-Coding 1032 ENSG00000129355
CDKN3 cyclin dependent kinase inhibitor 3 M-CDKN3-TB1, M-CDKN3-TB2

The protein encoded by this gene belongs to the dual specificity protein phosphatase family.

Protein-Coding 1033 ENSG00000100526
CENPE centromere protein E M-CENPE-TB1, M-CENPE-TB2

Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle.

Protein-Coding 1062 ENSG00000138778
CENPF centromere protein F M-CENPF-TB1, M-CENPF-TB2

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase.

Protein-Coding 1063 ENSG00000117724
CHEK1 checkpoint kinase 1 M-CHEK1-TB1, M-CHEK1-TB2

The protein encoded by this gene belongs to the Ser/Thr protein kinase family.

Protein-Coding 1111 ENSG00000149554
CKS1B CDC28 protein kinase regulatory subunit 1B M-CKS1B-TB1, M-CKS1B-TB2

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Protein-Coding 1163 ENSG00000173207
CKS2 CDC28 protein kinase regulatory subunit 2 M-CKS2-TB1, M-CKS2-TB2

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Protein-Coding 1164 ENSG00000123975
CSE1L chromosome segregation 1 like M-CSE1L-TB1, M-CSE1L-TB2

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer.

Protein-Coding 1434 ENSG00000124207
E2F1 E2F transcription factor 1 M-E2F1-TB1, M-E2F1-TB2

The protein encoded by this gene is a member of the E2F family of transcription factors.

Protein-Coding 1869 ENSG00000101412
GADD45A growth arrest and DNA damage inducible alpha M-GADD45A-TB1, M-GADD45A-TB2

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents.

Protein-Coding 1647 ENSG00000116717
INCENP inner centromere protein

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins

Protein-Coding 3619 ENSG00000149503
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) M-MAD2L1-TB1, M-MAD2L1-TB2

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.

Protein-Coding 4085 ENSG00000164109
MCM2 minichromosome maintenance complex component 2 M-MCM2-TB1, M-MCM2-TB2

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication.

Protein-Coding 4171 ENSG00000073111
MKI67 marker of proliferation Ki-67 M-MKI67-TB1, M-MKI67-TB2

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described.

Protein-Coding 4288 ENSG00000148773
NEK2 NIMA related kinase 2 M-NEK2-TB1, M-NEK2-TB2

This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation.

Protein-Coding 4751 ENSG00000117650
PCNA proliferating cell nuclear antigen M-PCNA-TB1, M-PCNA-TB2

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta.

Protein-Coding 5111 ENSG00000132646
RAD1 RAD1 checkpoint DNA exonuclease M-RAD1-TB1, M-RAD1-TB2

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete

Protein-Coding 5810 ENSG00000113456
RAD17 RAD17 checkpoint clamp loader component M-RAD17-TB1, M-RAD17-TB2

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in respo

Protein-Coding 5884 ENSG00000276618,ENSG00000152942
RAD21 RAD21 cohesin complex component

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesio

Protein-Coding 5885 ENSG00000164754
RAD51 RAD51 recombinase

The protein encoded by this gene is a member of the RAD51 protein family.

Protein-Coding 5888 ENSG00000051180
RAD51B RAD51 paralog B

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination.

Protein-Coding 5890 ENSG00000182185
RAD51D RAD51 paralog D

The protein encoded by this gene is a member of the RAD51 protein family.

Protein-Coding 5892 ENSG00000185379
RAD52 RAD52 homolog, DNA repair protein

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination.

Protein-Coding 5893 ENSG00000002016
RAD9A RAD9 checkpoint clamp component A

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair.

Protein-Coding 5883 ENSG00000172613
RB1 RB transcriptional corepressor 1

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found.

Protein-Coding 5925 ENSG00000139687
RBBP4 RB binding protein 4, chromatin remodeling factor

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins.

Protein-Coding 5928 ENSG00000162521
RHOA ras homolog family member A

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades.

Protein-Coding 387 ENSG00000067560
SKP1 S-phase kinase associated protein 1

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins.

Protein-Coding 6500 ENSG00000113558
SKP2 S-phase kinase associated protein 2

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

Protein-Coding 6502 ENSG00000145604
TP53 tumor protein p53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.

Protein-Coding 7157 ENSG00000141510
TP53BP1 tumor protein p53 binding protein 1 Protein-Coding 7158 ENSG00000067369
TP73 tumor protein p73

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development.

Protein-Coding 7161 ENSG00000078900
WEE1 WEE1 G2 checkpoint kinase

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases.

Protein-Coding 7465 ENSG00000166483