Apoptosis

Gene Name Onco-Tools Products Description Gene Type NCBI Gene ID Ensembl Gene
AIFM1 apoptosis inducing factor mitochondria associated 1 M-AIFM1-TB1, M-AIFM1-TB2

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells.

Protein-Coding 9131 ENSG00000156709
APAF1 apoptotic peptidase activating factor 1 M-APAF1-TB1, M-APAF1-TB2

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC).

Protein-Coding 317 ENSG00000120868
BAD BCL2 associated agonist of cell death

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death.

Protein-Coding 572 ENSG00000002330
BAK1 BCL2 antagonist/killer 1 M-BAK1-TB1, M-BAK1-TB2

The protein encoded by this gene belongs to the BCL2 protein family.

Protein-Coding 578 ENSG00000030110
BAX BCL2 associated X, apoptosis regulator

The protein encoded by this gene belongs to the BCL2 protein family.

Protein-Coding 581 ENSG00000087088
BBC3 BCL2 binding component 3

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass.

Protein-Coding 27113 ENSG00000105327
BCL2 BCL2, apoptosis regulator M-BCL2-TB1, M-BCL2-TB2

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes.

Protein-Coding 596 ENSG00000171791
BCL2A1 BCL2 related protein A1 M-BCL2A1-TB1, M-BCL2A1-TB2

This gene encodes a member of the BCL-2 protein family.

Protein-Coding 597 ENSG00000140379
BCL2L1 BCL2 like 1 M-BCL2L1-TB1, M-BCL2L1-TB2

The protein encoded by this gene belongs to the BCL-2 protein family.

Protein-Coding 598 ENSG00000171552
BCL2L10 BCL2 like 10 M-BCL2L10-TB1, M-BCL2L10-TB2

The protein encoded by this gene belongs to the BCL-2 protein family.

Protein-Coding 10017 ENSG00000137875
BCL2L11 BCL2 like 11 M-BCL2L11-TB1, M-BCL2L11-TB2

The protein encoded by this gene belongs to the BCL-2 protein family.

Protein-Coding 10018 ENSG00000153094
BCL2L12 BCL2 like 12 M-BCL2L12-TB1, M-BCL2L12-TB2

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2).

Protein-Coding 83596 ENSG00000126453
BCL2L14 BCL2 like 14

The protein encoded by this gene belongs to the BCL2 protein family.

Protein-Coding 79370
BCL2L2 BCL2 like 2

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators.

Protein-Coding 599 ENSG00000129473
BID BH3 interacting domain death agonist

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators.

Protein-Coding 637 ENSG00000015475
BIK BCL2 interacting killer M-BIK-TB1, M-BIK-TB2

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interactio

Protein-Coding 638 ENSG00000100290
BIRC2 baculoviral IAP repeat containing 2 M-BIRC2-TB1, M-BIRC2-TB2

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering

Protein-Coding 329 ENSG00000110330
BIRC3 baculoviral IAP repeat containing 3 M-BIRC3-TB1, M-BIRC3-TB2

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activat

Protein-Coding 330 ENSG00000023445
BIRC5 baculoviral IAP repeat containing 5 M-BIRC5-TB1, M-BIRC5-TB2

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death.

Protein-Coding 332 ENSG00000089685
BIRC6 baculoviral IAP repeat containing 6 M-BIRC6-TB1, M-BIRC6-TB2

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain.

Protein-Coding 57448 ENSG00000115760
BIRC7 baculoviral IAP repeat containing 7 M-BIRC7-TB1, M-BIRC7-TB2

This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain.

Protein-Coding 79444 ENSG00000101197
BMF Bcl2 modifying factor M-BMF-TB1, M-BMF-TB2

The protein encoded by this gene belongs to the BCL2 protein family.

Protein-Coding 90427 ENSG00000104081
BNIP3 BCL2 interacting protein 3

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor.

Protein-Coding 664 ENSG00000176171
BNIP3L BCL2 interacting protein 3 like

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain.

Protein-Coding 665 ENSG00000104765
BOK BOK, BCL2 family apoptosis regulator M-BOK-TB1, M-BOK-TB2

The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular

Protein-Coding 666 ENSG00000176720
CASP1 caspase 1 M-CASP1-TB1

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family.

Protein-Coding 834 ENSG00000137752
CASP10 caspase 10 M-CASP10-TB1, M-CASP10-TB2

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family.

Protein-Coding 843 ENSG00000003400
CASP14 caspase 14

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.

Protein-Coding 23581 ENSG00000105141
CASP2 caspase 2

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates.

Protein-Coding 835 ENSG00000106144
CASP3 caspase 3

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family.

Protein-Coding 836 ENSG00000164305
CASP4 caspase 4

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family.

Protein-Coding 837 ENSG00000196954
CASP5 caspase 5

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.

Protein-Coding 838 ENSG00000137757
CASP9 caspase 9

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.

Protein-Coding 839 ENSG00000132906
CCND1 cyclin D1 M-CCND1-TB1, M-CCND1-TB2, M-CCND1-TB3, M-CCND1-TB4

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle.

Protein-Coding 595 ENSG00000110092
CFLAR CASP8 and FADD like apoptosis regulator M-CFLAR-TB1, M-CFLAR-TB2, M-CFLAR-TB3, M-CFLAR-TB4

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8.

Protein-Coding 8837 ENSG00000003402
CYCS cytochrome c, somatic M-CYCS-TB1, M-CYCS-TB2

This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria.

Protein-Coding 54205 ENSG00000172115
DIABLO diablo IAP-binding mitochondrial protein

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.

Protein-Coding 842 ENSG00000184047
ENDOG endonuclease G M-ENDOG-TB1, M-ENDOG-TB2

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts.

Protein-Coding 2021 ENSG00000167136
FADD Fas associated via death domain M-FADD-TB1, M-FADD-TB2

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals.

Protein-Coding 8772 ENSG00000168040
FAS Fas cell surface death receptor M-FAS-TB1, M-FAS-TB2

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain.

Protein-Coding 355 ENSG00000026103
FASLG Fas ligand M-FASLG-TB1, M-FASLG-TB2

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS.

Protein-Coding 356 ENSG00000117560
HRK harakiri, BCL2 interacting protein M-HRK-TB1, M-HRK-TB2

This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes.

Protein-Coding 8739 ENSG00000135116
HTRA2 HtrA serine peptidase 2 M-HTRA2-TB1, M-HTRA2-TB2

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14.

Protein-Coding 27429 ENSG00000115317
MCL1 BCL2 family apoptosis regulator M-MCL1-TB1, M-MCL1-TB2

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants.

Protein-Coding 4170 ENSG00000143384
NAIP NLR family apoptosis inhibitory protein

This gene is part of a 500 kb inverted duplication on chromosome 5q13.

Protein-Coding 4671
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 M-PMAIP1-TB1, M-PMAIP1-TB2 Protein-Coding 5366 ENSG00000141682
TNF tumor necrosis factor M-TNF-TB1, M-TNF-TB2, M-TNF-TB3

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages.

Protein-Coding 7124
TNFRSF10A TNF receptor superfamily member 10a M-TNFRSF10A-TB1, M-TNFRSF10A-TB2

The protein encoded by this gene is a member of the TNF-receptor superfamily.

Protein-Coding 8797 ENSG00000104689
TNFRSF10B TNF receptor superfamily member 10b M-TNFRSF10B-TB1, M-TNFRSF10B-TB2

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain.

Protein-Coding 8795 ENSG00000120889
TNFRSF10C TNF receptor superfamily member 10c M-TNFRSF10C-TB1, M-TNFRSF10C-TB2

The protein encoded by this gene is a member of the TNF-receptor superfamily.

Protein-Coding 8794 ENSG00000173535
TNFRSF10D TNF receptor superfamily member 10d M-TNFRSF10D-TB1, M-TNFRSF10D-TB2

The protein encoded by this gene is a member of the TNF-receptor superfamily.

Protein-Coding 8793 ENSG00000173530
TNFRSF11B TNF receptor superfamily member 11b M-TNFRSF11B-TB1, M-TNFRSF11B-TB2

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption.

Protein-Coding 4982 ENSG00000164761
TNFSF10 tumor necrosis factor superfamily member 10 M-TNFSF10-TB1, M-TNFSF10-TB2

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family.

Protein-Coding 8743 ENSG00000121858
XIAP X-linked inhibitor of apoptosis M-XIAP-TB1, M-XIAP-TB2

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins.

Protein-Coding 331 ENSG00000101966