Apoptosis
Gene | Name | Onco-Tools Products | Description | Gene Type | NCBI Gene ID | Ensembl Gene |
---|---|---|---|---|---|---|
AIFM1 | apoptosis inducing factor mitochondria associated 1 | M-AIFM1-TB1, M-AIFM1-TB2 |
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. |
Protein-Coding | 9131 | ENSG00000156709 |
APAF1 | apoptotic peptidase activating factor 1 | M-APAF1-TB1, M-APAF1-TB2 |
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). |
Protein-Coding | 317 | ENSG00000120868 |
BAD | BCL2 associated agonist of cell death |
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. |
Protein-Coding | 572 | ENSG00000002330 | |
BAK1 | BCL2 antagonist/killer 1 | M-BAK1-TB1, M-BAK1-TB2 |
The protein encoded by this gene belongs to the BCL2 protein family. |
Protein-Coding | 578 | ENSG00000030110 |
BAX | BCL2 associated X, apoptosis regulator |
The protein encoded by this gene belongs to the BCL2 protein family. |
Protein-Coding | 581 | ENSG00000087088 | |
BBC3 | BCL2 binding component 3 |
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. |
Protein-Coding | 27113 | ENSG00000105327 | |
BCL2 | BCL2, apoptosis regulator | M-BCL2-TB1, M-BCL2-TB2 |
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. |
Protein-Coding | 596 | ENSG00000171791 |
BCL2A1 | BCL2 related protein A1 | M-BCL2A1-TB1, M-BCL2A1-TB2 |
This gene encodes a member of the BCL-2 protein family. |
Protein-Coding | 597 | ENSG00000140379 |
BCL2L1 | BCL2 like 1 | M-BCL2L1-TB1, M-BCL2L1-TB2 |
The protein encoded by this gene belongs to the BCL-2 protein family. |
Protein-Coding | 598 | ENSG00000171552 |
BCL2L10 | BCL2 like 10 | M-BCL2L10-TB1, M-BCL2L10-TB2 |
The protein encoded by this gene belongs to the BCL-2 protein family. |
Protein-Coding | 10017 | ENSG00000137875 |
BCL2L11 | BCL2 like 11 | M-BCL2L11-TB1, M-BCL2L11-TB2 |
The protein encoded by this gene belongs to the BCL-2 protein family. |
Protein-Coding | 10018 | ENSG00000153094 |
BCL2L12 | BCL2 like 12 | M-BCL2L12-TB1, M-BCL2L12-TB2 |
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). |
Protein-Coding | 83596 | ENSG00000126453 |
BCL2L14 | BCL2 like 14 |
The protein encoded by this gene belongs to the BCL2 protein family. |
Protein-Coding | 79370 | ||
BCL2L2 | BCL2 like 2 |
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. |
Protein-Coding | 599 | ENSG00000129473 | |
BID | BH3 interacting domain death agonist |
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. |
Protein-Coding | 637 | ENSG00000015475 | |
BIK | BCL2 interacting killer | M-BIK-TB1, M-BIK-TB2 |
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interactio |
Protein-Coding | 638 | ENSG00000100290 |
BIRC2 | baculoviral IAP repeat containing 2 | M-BIRC2-TB1, M-BIRC2-TB2 |
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering |
Protein-Coding | 329 | ENSG00000110330 |
BIRC3 | baculoviral IAP repeat containing 3 | M-BIRC3-TB1, M-BIRC3-TB2 |
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activat |
Protein-Coding | 330 | ENSG00000023445 |
BIRC5 | baculoviral IAP repeat containing 5 | M-BIRC5-TB1, M-BIRC5-TB2 |
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. |
Protein-Coding | 332 | ENSG00000089685 |
BIRC6 | baculoviral IAP repeat containing 6 | M-BIRC6-TB1, M-BIRC6-TB2 |
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. |
Protein-Coding | 57448 | ENSG00000115760 |
BIRC7 | baculoviral IAP repeat containing 7 | M-BIRC7-TB1, M-BIRC7-TB2 |
This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. |
Protein-Coding | 79444 | ENSG00000101197 |
BMF | Bcl2 modifying factor | M-BMF-TB1, M-BMF-TB2 |
The protein encoded by this gene belongs to the BCL2 protein family. |
Protein-Coding | 90427 | ENSG00000104081 |
BNIP3 | BCL2 interacting protein 3 |
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. |
Protein-Coding | 664 | ENSG00000176171 | |
BNIP3L | BCL2 interacting protein 3 like |
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. |
Protein-Coding | 665 | ENSG00000104765 | |
BOK | BOK, BCL2 family apoptosis regulator | M-BOK-TB1, M-BOK-TB2 |
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular |
Protein-Coding | 666 | ENSG00000176720 |
CASP1 | caspase 1 | M-CASP1-TB1 |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. |
Protein-Coding | 834 | ENSG00000137752 |
CASP10 | caspase 10 | M-CASP10-TB1, M-CASP10-TB2 |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. |
Protein-Coding | 843 | ENSG00000003400 |
CASP14 | caspase 14 |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. |
Protein-Coding | 23581 | ENSG00000105141 | |
CASP2 | caspase 2 |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. |
Protein-Coding | 835 | ENSG00000106144 | |
CASP3 | caspase 3 |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. |
Protein-Coding | 836 | ENSG00000164305 | |
CASP4 | caspase 4 |
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. |
Protein-Coding | 837 | ENSG00000196954 | |
CASP5 | caspase 5 |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. |
Protein-Coding | 838 | ENSG00000137757 | |
CASP9 | caspase 9 |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. |
Protein-Coding | 839 | ENSG00000132906 | |
CCND1 | cyclin D1 | M-CCND1-TB1, M-CCND1-TB2, M-CCND1-TB3, M-CCND1-TB4 |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. |
Protein-Coding | 595 | ENSG00000110092 |
CFLAR | CASP8 and FADD like apoptosis regulator | M-CFLAR-TB1, M-CFLAR-TB2, M-CFLAR-TB3, M-CFLAR-TB4 |
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. |
Protein-Coding | 8837 | ENSG00000003402 |
CYCS | cytochrome c, somatic | M-CYCS-TB1, M-CYCS-TB2 |
This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. |
Protein-Coding | 54205 | ENSG00000172115 |
DIABLO | diablo IAP-binding mitochondrial protein |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. |
Protein-Coding | 842 | ENSG00000184047 | |
ENDOG | endonuclease G | M-ENDOG-TB1, M-ENDOG-TB2 |
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. |
Protein-Coding | 2021 | ENSG00000167136 |
FADD | Fas associated via death domain | M-FADD-TB1, M-FADD-TB2 |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. |
Protein-Coding | 8772 | ENSG00000168040 |
FAS | Fas cell surface death receptor | M-FAS-TB1, M-FAS-TB2 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. |
Protein-Coding | 355 | ENSG00000026103 |
FASLG | Fas ligand | M-FASLG-TB1, M-FASLG-TB2 |
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. |
Protein-Coding | 356 | ENSG00000117560 |
HRK | harakiri, BCL2 interacting protein | M-HRK-TB1, M-HRK-TB2 |
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. |
Protein-Coding | 8739 | ENSG00000135116 |
HTRA2 | HtrA serine peptidase 2 | M-HTRA2-TB1, M-HTRA2-TB2 |
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. |
Protein-Coding | 27429 | ENSG00000115317 |
MCL1 | BCL2 family apoptosis regulator | M-MCL1-TB1, M-MCL1-TB2 |
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. |
Protein-Coding | 4170 | ENSG00000143384 |
NAIP | NLR family apoptosis inhibitory protein |
This gene is part of a 500 kb inverted duplication on chromosome 5q13. |
Protein-Coding | 4671 | ||
PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | M-PMAIP1-TB1, M-PMAIP1-TB2 | Protein-Coding | 5366 | ENSG00000141682 | |
TNF | tumor necrosis factor | M-TNF-TB1, M-TNF-TB2, M-TNF-TB3 |
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. |
Protein-Coding | 7124 | |
TNFRSF10A | TNF receptor superfamily member 10a | M-TNFRSF10A-TB1, M-TNFRSF10A-TB2 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. |
Protein-Coding | 8797 | ENSG00000104689 |
TNFRSF10B | TNF receptor superfamily member 10b | M-TNFRSF10B-TB1, M-TNFRSF10B-TB2 |
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. |
Protein-Coding | 8795 | ENSG00000120889 |
TNFRSF10C | TNF receptor superfamily member 10c | M-TNFRSF10C-TB1, M-TNFRSF10C-TB2 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. |
Protein-Coding | 8794 | ENSG00000173535 |
TNFRSF10D | TNF receptor superfamily member 10d | M-TNFRSF10D-TB1, M-TNFRSF10D-TB2 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. |
Protein-Coding | 8793 | ENSG00000173530 |
TNFRSF11B | TNF receptor superfamily member 11b | M-TNFRSF11B-TB1, M-TNFRSF11B-TB2 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. |
Protein-Coding | 4982 | ENSG00000164761 |
TNFSF10 | tumor necrosis factor superfamily member 10 | M-TNFSF10-TB1, M-TNFSF10-TB2 |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. |
Protein-Coding | 8743 | ENSG00000121858 |
XIAP | X-linked inhibitor of apoptosis | M-XIAP-TB1, M-XIAP-TB2 |
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. |
Protein-Coding | 331 | ENSG00000101966 |