Angiogenesis
Gene | Name | Onco-Tools Products | Description | Gene Type | NCBI Gene ID | Ensembl Gene |
---|---|---|---|---|---|---|
ADGRB1 | adhesion G protein-coupled receptor B1 | M-ADGRB1-TB1, M-ADGRB1-TB2 |
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. |
Protein-Coding | 575 | ENSG00000181790 |
ANGPT1 | angiopoietin 1 |
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. |
Protein-Coding | 284 | ENSG00000154188 | |
ANGPT2 | angiopoietin 2 | M-ANGPT2-TB1, M-ANGPT2-TB2 |
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). |
Protein-Coding | 285 | ENSG00000091879 |
ANGPTL3 | angiopoietin like 3 | M-ANGPTL3-TB1, M-ANGPTL3-TB2 |
This gene encodes a member of a family of secreted proteins that function in angiogenesis. |
Protein-Coding | 27329 | ENSG00000132855 |
ANGPTL4 | angiopoietin like 4 | M-ANGPTL4-TB1, M-ANGPTL4-TB2 |
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. |
Protein-Coding | 51129 | ENSG00000167772 |
COL4A3 | collagen type IV alpha 3 chain | M-COL4A3-TB1, M-COL4A3-TB2 |
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. |
Protein-Coding | 1285 | ENSG00000169031 |
EPHB1 | EPH receptor B1 |
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. |
Protein-Coding | 2047 | ENSG00000154928 | |
EREG | epiregulin | M-EREG-TB1 |
This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. |
Protein-Coding | 2069 | ENSG00000124882 |
ETS1 | ETS proto-oncogene 1, transcription factor |
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T |
Protein-Coding | 2113 | ENSG00000134954 | |
FGF1 | fibroblast growth factor 1 |
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. |
Protein-Coding | 2246 | ENSG00000113578 | |
FGF2 | fibroblast growth factor 2 | M-FGF2-TB1, M-FGF2-TB2 |
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. |
Protein-Coding | 2247 | ENSG00000138685 |
FLT1 | fms related tyrosine kinase 1 | M-FLT1-TB1, M-FLT1-TB2 |
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. |
Protein-Coding | 2321 | ENSG00000102755 |
FLT4 | fms related tyrosine kinase 4 | M-FLT4-TB1 |
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. |
Protein-Coding | 2324 | ENSG00000037280 |
HIF1A | hypoxia inducible factor 1 alpha subunit | M-HIF1A-TB1, M-HIF1A-TB2 |
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. |
Protein-Coding | 3091 | ENSG00000100644 |
KDR | kinase insert domain receptor | M-KDR-TB1, M-KDR-TB2 |
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. |
Protein-Coding | 3791 | ENSG00000128052 |
LAMA5 | laminin subunit alpha 5 | M-LAMA5-TB1, M-LAMA5-TB2 |
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. |
Protein-Coding | 3911 | ENSG00000130702 |
MIR126 | microRNA 126 |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl |
Non-Coding | 406913 | ENSG00000199161 | |
MIR132 | microRNA 132 | M-MIR132-TB1, M-MIR132-TB2 |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl |
Non-Coding | 406921 | ENSG00000267200 |
MIR296 | microRNA 296 |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl |
Non-Coding | 407022 | ENSG00000284040 | |
MIR503 | microRNA 503 |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl |
Non-Coding | 574506 | ENSG00000208005 | |
MIRLET7b | microRNA let-7b |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl |
Non-Coding | 406884 | ENSG00000284520 | |
NRP1 | neuropilin 1 | M-NRP1-TB1, M-NRP1-TB2 |
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. |
Protein-Coding | 8829 | ENSG00000099250 |
NRP2 | neuropilin 2 | M-NRP2-TB1, M-NRP2-TB2 |
This gene encodes a member of the neuropilin family of receptor proteins. |
Protein-Coding | 8828 | ENSG00000118257 |
PECAM1 | platelet and endothelial cell adhesion molecule 1 | M-PECAM1-TB1, M-PECAM1-TB2 |
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. |
Protein-Coding | 5175 | ENSG00000261371 |
PF4 | platelet factor 4 | M-PF4-TB1, M-PF4-TB2 |
This gene encodes a member of the CXC chemokine family. |
Protein-Coding | 5196 | ENSG00000163737 |
PGF | placental growth factor | M-PGF-TB1, M-PGF-TB2 |
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. |
Protein-Coding | 5228 | ENSG00000119630 |
PIGF | phosphatidylinositol glycan anchor biosynthesis class F | M-PIGF-TB1, M-PIGF-TB2 |
This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. |
Protein-Coding | 5281 | ENSG00000151665 |
PLXDC1 | plexin domain containing 1 | M-PLXDC1-TB1, M-PLXDC1-TB2 |
This gene plays a critical role in endothelial cell capillary morphogenesis |
Protein-Coding | 57125 | ENSG00000161381 |
PROK2 | prokineticin 2 |
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. |
Protein-Coding | 60675 | ENSG00000163421 | |
SERPINF1 | serpin family F member 1 | M-SERPINF1-TB1, M-SERPINF1-TB2 |
This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. |
Protein-Coding | 5176 | ENSG00000132386 |
STAB1 | stabilin 1 |
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. |
Protein-Coding | 23166 | ENSG00000010327 | |
TEK | TEK receptor tyrosine kinase |
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. |
Protein-Coding | 7010 | ENSG00000120156 | |
TIE1 | tyrosine kinase with immunoglobulin like and EGF like domains 1 |
This gene encodes a member of the tyrosine protein kinase family. |
Protein-Coding | 7075 | ENSG00000066056 | |
TNFAIP2 | TNF alpha induced protein 2 |
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. |
Protein-Coding | 7127 | ENSG00000185215 | |
TYMP | thymidine phosphorylase |
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. |
Protein-Coding | 1890 | ENSG00000025708 | |
VEGFA | vascular endothelial growth factor A |
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. |
Protein-Coding | 7422 | ENSG00000112715 | |
VEGFB | vascular endothelial growth factor B |
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. |
Protein-Coding | 7423 | ENSG00000173511 | |
VEGFC | vascular endothelial growth factor C |
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. |
Protein-Coding | 7424 | ENSG00000150630 | |
VEGFD | vascular endothelial growth factor D |
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endoth |
Protein-Coding | 2277 | ENSG00000165197 |