Angiogenesis

Gene Name Onco-Tools Products Description Gene Type NCBI Gene ID Ensembl Gene
ADGRB1 adhesion G protein-coupled receptor B1 M-ADGRB1-TB1, M-ADGRB1-TB2

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions.

Protein-Coding 575 ENSG00000181790
ANGPT1 angiopoietin 1

This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis.

Protein-Coding 284 ENSG00000154188
ANGPT2 angiopoietin 2 M-ANGPT2-TB1, M-ANGPT2-TB2

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK).

Protein-Coding 285 ENSG00000091879
ANGPTL3 angiopoietin like 3 M-ANGPTL3-TB1, M-ANGPTL3-TB2

This gene encodes a member of a family of secreted proteins that function in angiogenesis.

Protein-Coding 27329 ENSG00000132855
ANGPTL4 angiopoietin like 4 M-ANGPTL4-TB1, M-ANGPTL4-TB2

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain.

Protein-Coding 51129 ENSG00000167772
COL4A3 collagen type IV alpha 3 chain M-COL4A3-TB1, M-COL4A3-TB2

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits.

Protein-Coding 1285 ENSG00000169031
EPHB1 EPH receptor B1

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system.

Protein-Coding 2047 ENSG00000154928
EREG epiregulin M-EREG-TB1

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins.

Protein-Coding 2069 ENSG00000124882
ETS1 ETS proto-oncogene 1, transcription factor

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T

Protein-Coding 2113 ENSG00000134954
FGF1 fibroblast growth factor 1

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family.

Protein-Coding 2246 ENSG00000113578
FGF2 fibroblast growth factor 2 M-FGF2-TB1, M-FGF2-TB2

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities.

Protein-Coding 2247 ENSG00000138685
FLT1 fms related tyrosine kinase 1 M-FLT1-TB1, M-FLT1-TB2

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family.

Protein-Coding 2321 ENSG00000102755
FLT4 fms related tyrosine kinase 4 M-FLT4-TB1

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D.

Protein-Coding 2324 ENSG00000037280
HIF1A hypoxia inducible factor 1 alpha subunit M-HIF1A-TB1, M-HIF1A-TB2

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit.

Protein-Coding 3091 ENSG00000100644
KDR kinase insert domain receptor M-KDR-TB1, M-KDR-TB2

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF.

Protein-Coding 3791 ENSG00000128052
LAMA5 laminin subunit alpha 5 M-LAMA5-TB1, M-LAMA5-TB2

This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes.

Protein-Coding 3911 ENSG00000130702
MIR126 microRNA 126

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406913 ENSG00000199161
MIR132 microRNA 132 M-MIR132-TB1, M-MIR132-TB2

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406921 ENSG00000267200
MIR296 microRNA 296

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 407022 ENSG00000284040
MIR503 microRNA 503

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 574506 ENSG00000208005
MIRLET7b microRNA let-7b

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406884 ENSG00000284520
NRP1 neuropilin 1 M-NRP1-TB1, M-NRP1-TB2

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration.

Protein-Coding 8829 ENSG00000099250
NRP2 neuropilin 2 M-NRP2-TB1, M-NRP2-TB2

This gene encodes a member of the neuropilin family of receptor proteins.

Protein-Coding 8828 ENSG00000118257
PECAM1 platelet and endothelial cell adhesion molecule 1 M-PECAM1-TB1, M-PECAM1-TB2

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions.

Protein-Coding 5175 ENSG00000261371
PF4 platelet factor 4 M-PF4-TB1, M-PF4-TB2

This gene encodes a member of the CXC chemokine family.

Protein-Coding 5196 ENSG00000163737
PGF placental growth factor M-PGF-TB1, M-PGF-TB2

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor.

Protein-Coding 5228 ENSG00000119630
PIGF phosphatidylinositol glycan anchor biosynthesis class F M-PIGF-TB1, M-PIGF-TB2

This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis.

Protein-Coding 5281 ENSG00000151665
PLXDC1 plexin domain containing 1 M-PLXDC1-TB1, M-PLXDC1-TB2

This gene plays a critical role in endothelial cell capillary morphogenesis

Protein-Coding 57125 ENSG00000161381
PROK2 prokineticin 2

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock.

Protein-Coding 60675 ENSG00000163421
SERPINF1 serpin family F member 1 M-SERPINF1-TB1, M-SERPINF1-TB2

This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins.

Protein-Coding 5176 ENSG00000132386
STAB1 stabilin 1

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging.

Protein-Coding 23166 ENSG00000010327
TEK TEK receptor tyrosine kinase

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family.

Protein-Coding 7010 ENSG00000120156
TIE1 tyrosine kinase with immunoglobulin like and EGF like domains 1

This gene encodes a member of the tyrosine protein kinase family.

Protein-Coding 7075 ENSG00000066056
TNFAIP2 TNF alpha induced protein 2

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells.

Protein-Coding 7127 ENSG00000185215
TYMP thymidine phosphorylase

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells.

Protein-Coding 1890 ENSG00000025708
VEGFA vascular endothelial growth factor A

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer.

Protein-Coding 7422 ENSG00000112715
VEGFB vascular endothelial growth factor B

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family.

Protein-Coding 7423 ENSG00000173511
VEGFC vascular endothelial growth factor C

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family.

Protein-Coding 7424 ENSG00000150630
VEGFD vascular endothelial growth factor D

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endoth

Protein-Coding 2277 ENSG00000165197