Abnormal Metabolism

Gene Name Onco-Tools Products Description Gene Type NCBI Gene ID Ensembl Gene
ACACA acetyl-CoA carboxylase alpha

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system.

Protein-Coding 31 ENSG00000278540
ACLY ATP citrate lyase M-ACLY-TB1, M-ACLY-TB2, M-ACLY-TB3

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.

Protein-Coding 47 ENSG00000131473
CTPS1 CTP synthase 1 M-CTPS1-TB1, M-CTPS1-TB2, M-CTPS1-TB3, M-CTPS1-TB4

This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate).

Protein-Coding 1503 ENSG00000171793
CTPS2 CTP synthase 2 M-CTPS2-TB1

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate.

Protein-Coding 56474 ENSG00000047230
DHFR dihydrofolate reductase

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.

Protein-Coding 1719 ENSG00000228716
FASN fatty acid synthase M-FASN-TB1

The enzyme encoded by this gene is a multifunctional protein.

Protein-Coding 2194 ENSG00000169710
FH fumarate hydratase M-FH-TB1, M-FH-TB2

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate.

Protein-Coding 2271 ENSG00000091483
G6PD glucose-6-phosphate dehydrogenase M-G6PD-TB1, M-G6PD-TB2, M-G6PD-TB3, M-G6PD-TB4

This gene encodes glucose-6-phosphate dehydrogenase.

Protein-Coding 2539 ENSG00000160211
GPI glucose-6-phosphate isomerase M-GPI-TB1, M-GPI-TB3, M-GPI-TB4

This gene encodes a member of the glucose phosphate isomerase protein family.

Protein-Coding 2821 ENSG00000105220
IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic M-IDH1-TB1, M-IDH1-TB2

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.

Protein-Coding 3417 ENSG00000138413
IMPDH1 inosine monophosphate dehydrogenase 1 M-IMPDH1-TB1, M-IMPDH1-TB2

The protein encoded by this gene acts as a homotetramer to regulate cell growth.

Protein-Coding 3614 ENSG00000106348
IMPDH2 inosine monophosphate dehydrogenase 2 M-IMPDH2-TB1, M-IMPDH2-TB2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis.

Protein-Coding 3615 ENSG00000178035
LDHA lactate dehydrogenase A M-LDHA-TB1, M-LDHA-TB2

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis.

Protein-Coding 3939 ENSG00000134333
MIR143 microRNA 143

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406935 ENSG00000284182
MIR155 microRNA 155

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 406947 ENSG00000283904
MIR26A1 microRNA 26a-1

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 407015 ENSG00000199075
MIR375 microRNA 375

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and transl

Non-Coding 494324 ENSG00000198973
PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 M-PRKAA1-TB1, M-PRKAA2-TB1

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK).

Protein-Coding 5562 ENSG00000132356
PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK).

Protein-Coding 5563 ENSG00000162409
PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 M-PRKAB1-TB1, M-PRKAB1-TB2

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK).

Protein-Coding 5564 ENSG00000111725
PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 M-PRKAG1-TB1, M-PRKAG1-TB2

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK).

Protein-Coding 5571 ENSG00000181929
RRM1 ribonucleotide reductase catalytic subunit M1

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides.

Protein-Coding 6240 ENSG00000167325
RRM2 ribonucleotide reductase regulatory subunit M2 M-RRM2-TB1, M-RRM2-TB2, M-RRM2-TB3

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides.

Protein-Coding 6241 ENSG00000171848
RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase.

Protein-Coding 50484 ENSG00000048392
SDHB succinate dehydrogenase complex iron sulfur subunit B M-SDHB-TB1, M-SDHB-TB2

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ.

Protein-Coding 6390 ENSG00000117118
SDHC succinate dehydrogenase complex subunit C M-SDHC-TB1

This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobi

Protein-Coding 6391 ENSG00000143252
SDHD succinate dehydrogenase complex subunit D M-SDHD-TB1, M-SDHD-TB2

This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate.

Protein-Coding 6392 ENSG00000255292,ENSG00000204370
SLC2A1 solute carrier family 2 member 1 M-SLC2A1-TB1, M-SLC2A1-TB2

This gene encodes a major glucose transporter in the mammalian blood-brain barrier.

Protein-Coding 6513 ENSG00000117394
SLC2A3 solute carrier family 2 member 3 M-SLC2A3-TB1, M-SLC2A3-TB2 Protein-Coding 6515 ENSG00000059804
SLC2A4 solute carrier family 2 member 4 M-SLC2A4-TB1, M-SLC2A4-TB2

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter.

Protein-Coding 6517 ENSG00000181856
STK11 serine/threonine kinase 11 M-STK11-TB1, M-STK11-TB2

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor.

Protein-Coding 6794 ENSG00000118046
TKTL1 transketolase like 1 M-TKTL1-TB1, M-TKTL1-TB2, M-TKTL1-TB3, M-TKTL1-TB4

The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D

Protein-Coding 8277 ENSG00000007350
TYMS thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor.

Protein-Coding 7298 ENSG00000176890