AXIN1

Categories: 
Full Name: 
axin 1
Aliases: 
AXIN; PPP1R49
Gene Type: 
Protein-Coding

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

M-AXIN1-TB1

Title:
M-AXIN1-TB1-100n
SKU:
M1603-1A
Species: 
Hs
Product Type: 
Translation Blocker
Transcript Type: 
Protein-Coding
Target Region: 

ctcattgttc cttgacgcag agtcccaaa(atg)aatatcca agagcagggt ttcc

Price: 
$250.00

M-AXIN1-TB2

Title:
M-AXIN1-TB2-100n
SKU:
M1603-2A
Species: 
Hs
Product Type: 
Translation Blocker
Transcript Type: 
Protein-Coding
Target Region: 

ctgtaagtac tgatgtatta gggtgcagcg ctcattgttc cttgacgcag agtcccaaa(atg)aatatcca agagcagggt ttcc

Price: 
$250.00