APAF1

Categories: 
Full Name: 
apoptotic peptidase activating factor 1
Aliases: 
CED4; APAF-1
Gene Type: 
Protein-Coding

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

M-APAF1-TB1

Title:
M-APAF1-TB1-100n
SKU:
M1202-1A
Species: 
Hs
Product Type: 
Translation Blocker
Transcript Type: 
Protein-Coding
Target Region: 

tggttgacag ctcagagaga gaaagatctg agggaag(atg) gatgcaaaag ctcgaaattg tt

Price: 
$250.00

M-APAF1-TB2

Title:
M-APAF1-TB2-100n
SKU:
M1202-2A
Species: 
Hs
Product Type: 
Translation Blocker
Transcript Type: 
Protein-Coding
Target Region: 

tggttgacag ctcagagaga gaaagatctg agggaag(atg) gatgcaaaag ctcgaaattg tt

Price: 
$250.00