AKT2

Categories: 
Full Name: 
AKT serine/threonine kinase 2
Aliases: 
PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
Gene Type: 
Protein-Coding

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]

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