AIFM1

Categories: 
Full Name: 
apoptosis inducing factor mitochondria associated 1
Aliases: 
AIF; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6
Gene Type: 
Protein-Coding

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]

M-AIFM1-TB1

Title:
M-AIFM1-TB1-100n
SKU:
M1201-1A
Species: 
Hs
Product Type: 
Translation Blocker
Transcript Type: 
Protein-Coding
Target Region: 

tcgtgcgtga gaggaaaggg aaggaggagg tcccgaatag cggtcgccga a(atg)ttccgg tgtggaggcc tggcgg

Price: 
$250.00

M-AIFM1-TB2

Title:
M-AIFM1-TB2-100n
SKU:
M1201-2A
Species: 
Hs
Product Type: 
Translation Blocker
Transcript Type: 
Protein-Coding
Target Region: 

tcgtgcgtga gaggaaaggg aaggaggagg tcccgaatag cggtcgccga a(atg)ttccgg tgtggaggcc tggcgg

Price: 
$250.00
Product Note: 
high CT content