Genes Listed Alphabetically

A (18) | B (30) | C (85) | D (12) | E (24) | F (18) | G (5) | H (26) | I (29) | J (2) | K (21) | L (3) | M (69) | N (16) | P (29) | R (26) | S (36) | T (30) | U (4) | V (5) | W (5) | X (2) | Y (1)
Gene Name Onco-Tools Products Description Categories Gene Type NCBI Gene ID Ensembl Gene
IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic M-IDH1-TB1, M-IDH1-TB2

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.

Abnormal Metabolism Protein-Coding 3417 ENSG00000138413
IDO1 indoleamine 2,3-dioxygenase 1 M-IDO1-TB1, M-IDO1-TB2

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine.

Immune System Evasion Protein-Coding 3620 ENSG00000131203
IDO2 indoleamine 2,3-dioxygenase 2 M-IDO2-TB1, M-IDO2-TB2

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMe

Immune System Evasion Protein-Coding 169355 ENSG00000188676
IFNG interferon gamma M-IFNG-TB1, M-IFNG-TB2

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems.

Inflammation Protein-Coding 3458 ENSG00000111537
IGF1 insulin like growth factor 1

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development.

Cell Signaling Protein-Coding 3479 ENSG00000017427
IGF1R insulin like growth factor 1 receptor M-IGF1R-TB1, M-IGF1R-TB2

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events.

Cell Signaling Protein-Coding 3480 ENSG00000140443
IGF2 insulin like growth factor 2

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth.

Cell Signaling Protein-Coding 3481 ENSG00000167244
IGF2R insulin like growth factor 2 receptor M-IGF2R-TB1, M-IGF2R-TB2

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein.

Cell Signaling Protein-Coding 3482 ENSG00000197081
IL10 interleukin 10 M-IL10-TB1

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation.

Inflammation Protein-Coding 3586 ENSG00000136634
IL12A interleukin 12A M-IL12A-TB1, M-IL12A-TB2

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities.

Inflammation Protein-Coding 3592 ENSG00000168811
IL12B interleukin 12B M-IL12B-TB1, M-IL12B-TB2

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities.

Inflammation Protein-Coding 3593 ENSG00000113302
IL13 interleukin 13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation.

Inflammation Protein-Coding 3596 ENSG00000169194
IL17A interleukin 17A M-IL17A-TB1, M-IL17A-TB2

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases.

Inflammation Protein-Coding 3605 ENSG00000112115
IL18 interleukin 18 M-IL18-TB1, M-IL18-TB2

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells.

Metastasis Protein-Coding 3606 ENSG00000150782
IL1A interleukin 1 alpha M-IL1A-TB1, M-IL1A-TB2

The protein encoded by this gene is a member of the interleukin 1 cytokine family.

Inflammation Protein-Coding 3552 ENSG00000115008
IL1B interleukin 1 beta M-IL1B-TB1, M-IL1B-TB2, M-IL1B-TB3, M-IL1B-TB4

The protein encoded by this gene is a member of the interleukin 1 cytokine family.

Inflammation, Metastasis Protein-Coding 3553 ENSG00000125538
IL1R1 interleukin 1 receptor type 1

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family.

Inflammation Protein-Coding 3554 ENSG00000115594
IL2 interleukin 2 M-IL2-TB1

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes.

Inflammation Protein-Coding 3558 ENSG00000109471
IL23A interleukin 23 subunit alpha M-IL23A-TB1, M-IL23A-TB2

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B).

Inflammation Protein-Coding 51561 ENSG00000110944
IL4 interleukin 4 M-IL4-TB1, M-IL4-TB2

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor.

Inflammation Protein-Coding 3565 ENSG00000113520
IL6 interleukin 6 M-IL6-TB1, M-IL6-TB2, M-IL6-TB3, M-IL6-TB4

This gene encodes a cytokine that functions in inflammation and the maturation of B cells.

Inflammation Protein-Coding 3569 ENSG00000136244
IL8 C-X-C motif chemokine ligand 8 M-IL8-TB1, M-IL8-TB2

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response.

Inflammation Protein-Coding 3576 ENSG00000169429
IMPDH1 inosine monophosphate dehydrogenase 1 M-IMPDH1-TB1, M-IMPDH1-TB2

The protein encoded by this gene acts as a homotetramer to regulate cell growth.

Abnormal Metabolism Protein-Coding 3614 ENSG00000106348
IMPDH2 inosine monophosphate dehydrogenase 2 M-IMPDH2-TB1, M-IMPDH2-TB2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis.

Abnormal Metabolism Protein-Coding 3615 ENSG00000178035
INCENP inner centromere protein

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins

Cell Cycle & DNA Repair Protein-Coding 3619 ENSG00000149503
INPP4B inositol polyphosphate-4-phosphatase type II B

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways.

Cell Signaling Protein-Coding 8821 ENSG00000109452
INSR insulin receptor M-INSR-TB1, M-INSR-TB2

This gene encodes a member of the receptor tyrosine kinase family of proteins.

Cell Signaling Protein-Coding 3643 ENSG00000171105
ITGA7 integrin subunit alpha 7 M-ITGA7-TB1, M-ITGA7-TB2, M-ITGA7-TB3, M-ITGA7-TB4

The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

Metastasis Protein-Coding 3679 ENSG00000135424
ITGB3 integrin subunit beta 3

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain.

Metastasis Protein-Coding 3690 ENSG00000259207