Genes Listed Alphabetically
Gene | Name | Onco-Tools Products | Description | Categories | Gene Type | NCBI Gene ID | Ensembl Gene |
---|---|---|---|---|---|---|---|
IDH1 | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | M-IDH1-TB1, M-IDH1-TB2 |
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. |
Abnormal Metabolism | Protein-Coding | 3417 | ENSG00000138413 |
IDO1 | indoleamine 2,3-dioxygenase 1 | M-IDO1-TB1, M-IDO1-TB2 |
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. |
Immune System Evasion | Protein-Coding | 3620 | ENSG00000131203 |
IDO2 | indoleamine 2,3-dioxygenase 2 | M-IDO2-TB1, M-IDO2-TB2 |
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMe |
Immune System Evasion | Protein-Coding | 169355 | ENSG00000188676 |
IFNG | interferon gamma | M-IFNG-TB1, M-IFNG-TB2 |
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. |
Inflammation | Protein-Coding | 3458 | ENSG00000111537 |
IGF1 | insulin like growth factor 1 |
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. |
Cell Signaling | Protein-Coding | 3479 | ENSG00000017427 | |
IGF1R | insulin like growth factor 1 receptor | M-IGF1R-TB1, M-IGF1R-TB2 |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. |
Cell Signaling | Protein-Coding | 3480 | ENSG00000140443 |
IGF2 | insulin like growth factor 2 |
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. |
Cell Signaling | Protein-Coding | 3481 | ENSG00000167244 | |
IGF2R | insulin like growth factor 2 receptor | M-IGF2R-TB1, M-IGF2R-TB2 |
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. |
Cell Signaling | Protein-Coding | 3482 | ENSG00000197081 |
IL10 | interleukin 10 | M-IL10-TB1 |
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. |
Inflammation | Protein-Coding | 3586 | ENSG00000136634 |
IL12A | interleukin 12A | M-IL12A-TB1, M-IL12A-TB2 |
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. |
Inflammation | Protein-Coding | 3592 | ENSG00000168811 |
IL12B | interleukin 12B | M-IL12B-TB1, M-IL12B-TB2 |
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. |
Inflammation | Protein-Coding | 3593 | ENSG00000113302 |
IL13 | interleukin 13 |
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. |
Inflammation | Protein-Coding | 3596 | ENSG00000169194 | |
IL17A | interleukin 17A | M-IL17A-TB1, M-IL17A-TB2 |
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. |
Inflammation | Protein-Coding | 3605 | ENSG00000112115 |
IL18 | interleukin 18 | M-IL18-TB1, M-IL18-TB2 |
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. |
Metastasis | Protein-Coding | 3606 | ENSG00000150782 |
IL1A | interleukin 1 alpha | M-IL1A-TB1, M-IL1A-TB2 |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. |
Inflammation | Protein-Coding | 3552 | ENSG00000115008 |
IL1B | interleukin 1 beta | M-IL1B-TB1, M-IL1B-TB2, M-IL1B-TB3, M-IL1B-TB4 |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. |
Inflammation, Metastasis | Protein-Coding | 3553 | ENSG00000125538 |
IL1R1 | interleukin 1 receptor type 1 |
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. |
Inflammation | Protein-Coding | 3554 | ENSG00000115594 | |
IL2 | interleukin 2 | M-IL2-TB1 |
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. |
Inflammation | Protein-Coding | 3558 | ENSG00000109471 |
IL23A | interleukin 23 subunit alpha | M-IL23A-TB1, M-IL23A-TB2 |
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). |
Inflammation | Protein-Coding | 51561 | ENSG00000110944 |
IL4 | interleukin 4 | M-IL4-TB1, M-IL4-TB2 |
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. |
Inflammation | Protein-Coding | 3565 | ENSG00000113520 |
IL6 | interleukin 6 | M-IL6-TB1, M-IL6-TB2, M-IL6-TB3, M-IL6-TB4 |
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. |
Inflammation | Protein-Coding | 3569 | ENSG00000136244 |
IL8 | C-X-C motif chemokine ligand 8 | M-IL8-TB1, M-IL8-TB2 |
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. |
Inflammation | Protein-Coding | 3576 | ENSG00000169429 |
IMPDH1 | inosine monophosphate dehydrogenase 1 | M-IMPDH1-TB1, M-IMPDH1-TB2 |
The protein encoded by this gene acts as a homotetramer to regulate cell growth. |
Abnormal Metabolism | Protein-Coding | 3614 | ENSG00000106348 |
IMPDH2 | inosine monophosphate dehydrogenase 2 | M-IMPDH2-TB1, M-IMPDH2-TB2 |
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. |
Abnormal Metabolism | Protein-Coding | 3615 | ENSG00000178035 |
INCENP | inner centromere protein |
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins |
Cell Cycle & DNA Repair | Protein-Coding | 3619 | ENSG00000149503 | |
INPP4B | inositol polyphosphate-4-phosphatase type II B |
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. |
Cell Signaling | Protein-Coding | 8821 | ENSG00000109452 | |
INSR | insulin receptor | M-INSR-TB1, M-INSR-TB2 |
This gene encodes a member of the receptor tyrosine kinase family of proteins. |
Cell Signaling | Protein-Coding | 3643 | ENSG00000171105 |
ITGA7 | integrin subunit alpha 7 | M-ITGA7-TB1, M-ITGA7-TB2, M-ITGA7-TB3, M-ITGA7-TB4 |
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. |
Metastasis | Protein-Coding | 3679 | ENSG00000135424 |
ITGB3 | integrin subunit beta 3 |
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. |
Metastasis | Protein-Coding | 3690 | ENSG00000259207 |